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Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States

The critical and multiple roles of thrombin in blood coagulation are regulated by ligands and cofactors. Zymogen activation imparts proteolytic activity to thrombin and also affects the binding of ligands to its two principal exosites. We have used the activation peptide fragment 1.2 (F12), a ligand...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kamath, Parvathi, Huntington, James A., Krishnaswamy, Sriram
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937891/
https://ncbi.nlm.nih.gov/pubmed/20639195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154914
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