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Loop-Sheet Mechanism of Serpin Polymerization Tested by Reactive Center Loop Mutations
The serpin mechanism of protease inhibition involves the rapid and stable incorporation of the reactive center loop (RCL) into central β-sheet A. Serpins therefore require a folding mechanism that bypasses the most stable “loop-inserted” conformation to trap the RCL in an exposed and metastable stat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945569/ https://ncbi.nlm.nih.gov/pubmed/20667823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156042 |
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