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Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12)

Many members of the serine protease inhibitor (serpin) family are activated by glycosaminoglycans (GAGs). Visceral adipose tissue-derived serpin (vaspin), serpin A12 of the serpin family, and its target protease kallikrein 7 (KLK7) are heparin-binding proteins, and inhibition of KLK7 by vaspin is ac...

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Vydáno v:J Biol Chem
Hlavní autoři: Ulbricht, David, Oertwig, Kathrin, Arnsburg, Kristin, Saalbach, Anja, Pippel, Jan, Sträter, Norbert, Heiker, John T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247670/
https://ncbi.nlm.nih.gov/pubmed/27941022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748020
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