Vaspin inhibits kallikrein 7 by serpin mechanism

The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal structure and identify human kallikrein 7 (hK7) as a first protease target of vaspin inhibited by classical serpin mechanism with h...

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Autors principals: Heiker, John T., Klöting, Nora, Kovacs, Peter, Kuettner, E. Bartholomeus, Sträter, Norbert, Schultz, Stephan, Kern, Matthias, Stumvoll, Michael, Blüher, Matthias, Beck-Sickinger, Annette G.
Format: Artigo
Idioma:Inglês
Publicat: SP Birkhäuser Verlag Basel 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689916/
https://ncbi.nlm.nih.gov/pubmed/23370777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1258-8
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