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The Critical Role of Hinge Region Expulsion in the Induced-fit Heparin Binding Mechanism of Antithrombin
Antithrombin (AT) is the most important inhibitor of the coagulation proteases. Its activity is stimulated by glycosaminoglycans such as heparin, through allosteric and template mechanisms. AT utilises an induced-fit mechanism to bind with high affinity to a pentasaccharide sequence found in about o...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697666/ https://ncbi.nlm.nih.gov/pubmed/19452598 |
| Oznake: |
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