The Critical Role of Hinge Region Expulsion in the Induced-fit Heparin Binding Mechanism of Antithrombin

Antithrombin (AT) is the most important inhibitor of the coagulation proteases. Its activity is stimulated by glycosaminoglycans such as heparin, through allosteric and template mechanisms. AT utilises an induced-fit mechanism to bind with high affinity to a pentasaccharide sequence found in about o...

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Bibliographic Details
Main Authors: Langdown, Jonathan, Belzar, Klara J., Savory, Wendy J., Baglin, Trevor P., Huntington, James A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697666/
https://ncbi.nlm.nih.gov/pubmed/19452598
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