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COOPERATIVE INTERACTIONS OF THREE HOTSPOT HEPARIN BINDING RESIDUES ARE CRITICAL FOR ALLOSTERIC ACTIVATION OF ANTITHROMBIN BY HEPARIN
Heparin allosterically activates the anticoagulant serpin, antithrombin, by binding through a sequence-specific pentasaccharide and inducing activating conformational changes in the protein. Three basic residues of antithrombin, Lys114, Lys125 and Arg129, have been shown to be hotspots for binding t...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363533/ https://ncbi.nlm.nih.gov/pubmed/29561141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00216 |
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