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Kinetic Evidence that Allosteric Activation of Antithrombin by Heparin Is Mediated by Two Sequential Conformational Changes

The serpin, antithrombin, requires allosteric activation by a sequence-specific pentasaccharide unit of heparin or heparan sulfate glycosaminoglycans to function as an anticoagulant regulator of blood clotting proteases. Surprisingly, X-ray structures have shown that the pentasaccharide produces sim...

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Detaylı Bibliyografya
Asıl Yazarlar: Schedin-Weiss, Sophia, Richard, Benjamin, Olson, Steven T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965262/
https://ncbi.nlm.nih.gov/pubmed/20816747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.08.021
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