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Kinetic Evidence that Allosteric Activation of Antithrombin by Heparin Is Mediated by Two Sequential Conformational Changes
The serpin, antithrombin, requires allosteric activation by a sequence-specific pentasaccharide unit of heparin or heparan sulfate glycosaminoglycans to function as an anticoagulant regulator of blood clotting proteases. Surprisingly, X-ray structures have shown that the pentasaccharide produces sim...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965262/ https://ncbi.nlm.nih.gov/pubmed/20816747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.08.021 |
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