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Kinetic Evidence that Allosteric Activation of Antithrombin by Heparin Is Mediated by Two Sequential Conformational Changes

The serpin, antithrombin, requires allosteric activation by a sequence-specific pentasaccharide unit of heparin or heparan sulfate glycosaminoglycans to function as an anticoagulant regulator of blood clotting proteases. Surprisingly, X-ray structures have shown that the pentasaccharide produces sim...

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Autors principals: Schedin-Weiss, Sophia, Richard, Benjamin, Olson, Steven T.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965262/
https://ncbi.nlm.nih.gov/pubmed/20816747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.08.021
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