Saturation Mutagenesis of the Antithrombin Reactive Center Loop P14 Residue Supports a Three-step Mechanism of Heparin Allosteric Activation Involving Intermediate and Fully Activated States

Past studies have suggested that a key feature of the mechanism of heparin allosteric activation of the anticoagulant serpin, antithrombin, is the release of the reactive center loop P14 residue from a native state stabilizing interaction with the hydrophobic core. However, more recent studies have...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Roth, Ryan, Swanson, Richard, Izaguirre, Gonzalo, Bock, Susan C., Gettins, Peter G. W., Olson, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653662/
https://ncbi.nlm.nih.gov/pubmed/26359493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678839
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