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Crystal Structure of Monomeric Native Antithrombin Reveals a Novel Reactive Center Loop Conformation
The poor inhibitory activity of circulating antithrombin (AT) is critical to the formation of blood clots at sites of vascular damage. AT becomes an efficient inhibitor of the coagulation proteases only after binding to a specific heparin pentasaccharide, which alters the conformation of the reactiv...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2679979/ https://ncbi.nlm.nih.gov/pubmed/16973611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607204200 |
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