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Crystal Structure of Monomeric Native Antithrombin Reveals a Novel Reactive Center Loop Conformation

The poor inhibitory activity of circulating antithrombin (AT) is critical to the formation of blood clots at sites of vascular damage. AT becomes an efficient inhibitor of the coagulation proteases only after binding to a specific heparin pentasaccharide, which alters the conformation of the reactiv...

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Detalhes bibliográficos
Main Authors: Johnson, Daniel J. D., Langdown, Jonathan, Li, Wei, Luis, Stephan A., Baglin, Trevor P., Huntington, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679979/
https://ncbi.nlm.nih.gov/pubmed/16973611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607204200
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