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Antithrombin–S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
Regulation of blood coagulation is critical for maintaining blood flow, while preventing excessive bleeding or thrombosis. One of the principal regulatory mechanisms involves heparin activation of the serpin antithrombin (AT). Inhibition of several coagulation proteases is accelerated by up to 10 00...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456925/ https://ncbi.nlm.nih.gov/pubmed/16619025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601089 |
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