The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties

Por Kumar, Raj, Ujjinamatada, Ravi K., Hosmane, Ramachandra S.
Publicado em 2008

An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-y...

Por Ujjinamatada, Ravi K., Baier, Andrea, Borowski, Peter, Hosmane, Ramachandra S.
Publicado em 2007

Structure-activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system

Por Zhang, Peng, Zhang, Ning, Korba, Brent E., Hosmane, Ramachandra S.
Publicado em 2007

Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role...

Por Zhang, Peng, Zhang, Ning, Buckwold, Victor E., Hosmane, Ramachandra S.
Publicado em 2007

A Novel Transition State Analogue Inhibitor of Guanase Based on Azepinomycin Ring Structure: Synthesis and Biochemical Assessment of Enzyme Inhibition

Por Chakraborty, Saibal, Shah, Niti H., Fishbein, James C., Hosmane, Ramachandra S.
Publicado em 2011

Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues

Por Chakraborty, Saibal, Shah, Niti H., Fishbein, James C., Hosmane, Ramachandra S.
Publicado em 2012

Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring System. In vitro results and implications

Por Zhang, Ning, Zhang, Peng, Baier, Andrea, Cova, Lucyna, Hosmane, Ramachandra S.
Publicado em 2014

Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively...

Por Tantravedi, Saritha, Chakraborty, Saibal, Shah, Niti H., Fishbein, James C., Hosmane, Ramachandra S.
Publicado em 2013

Identification of Small Molecules That Suppress MicroRNA Function and Reverse Tumorigenesis

Por Watashi, Koichi, Yeung, Man Lung, Starost, Matthew F., Hosmane, Ramachandra S., Jeang, Kuan-Teh
Publicado em 2010

Characterization of Imidazo[4,5-d]Pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus Nucleoside Triphosphatase/Helicase: Evidence for Activity o...

Por Borowski, Peter, Lang, Melanie, Haag, Annemarie, Schmitz, Herbert, Choe, Joonho, Chen, Huan-Ming, Hosmane, Ramachandra S.
Publicado em 2002

A Novel, Broad Spectrum Anti-Cancer Compound Containing the Imidazo[4,5-e][1,3]diazepine Ring System

Por Xie, Min, Ujjinamatada, Ravi K., Sadowska, Mariola, Lapidus, Rena G., Edelman, Martin J., Hosmane, Ramachandra S.
Publicado em 2010

Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency virus type 1 Replication

Por Yedavalli, Venkat S.R.K, Zhang, Ning, Cai, Hongyi, Zhang, Peng, Starost, Matthew F., Hosmane, Ramachandra S., Jeang, Kuan-Teh
Publicado em 2008

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4′,5′-f][1,3]diazepines

Por Kondaskar, Atul, Kondaskar, Shilpi, Fishbein, James C., Carter-Cooper, Brandon A., Lapidus, Rena G., Sadowska, Mariola, Edelman, Martin J., Hosmane, Ramachandra S.
Publicado em 2012

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

Por Xie, Min, Vesuna, Farhad, Botlagunta, Mahendran, Bol, Guus Martinus, Irving, Ashley, Bergman, Yehudit, Hosmane, Ramachandra S., Kato, Yoshinori, Winnard, Paul T., Raman, Venu
Publicado no Oncotarget (2015)

Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System

Por Kondaskar, Atul, Kondaskar, Shilpi, Kumar, Raj, Fishbein, James C., Muvarak, Nidal, Lapidus, Rena G., Sadowska, Mariola, Edelman, Martin J., Bol, Guus M., Vesuna, Farhad, Raman, Venu, Hosmane, Ramachandra S.
Publicado em 2010

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

Por Bol, Guus M, Vesuna, Farhad, Xie, Min, Zeng, Jing, Aziz, Khaled, Gandhi, Nishant, Levine, Anne, Irving, Ashley, Korz, Dorian, Tantravedi, Saritha, Heerma van Voss, Marise R, Gabrielson, Kathleen, Bordt, Evan A, Polster, Brian M, Cope, Leslie, van der Groep, Petra, Kondaskar, Atul, Rudek, Michelle A, Hosmane, Ramachandra S, van der Wall, Elsken, van Diest, Paul J, Tran, Phuoc T, Raman, Venu
Publicado no EMBO Mol Med (2015)