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Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively Substituted Imidazo[4,5-e][1,4]diazepines

Guanase is an important enzyme of the purine salvage pathway of nucleic acid metabolism and its inhibition has beneficial implications in viral, bacterial, and cancer therapy. The work described herein is based on a hypothesis that azepinomycin, a heterocyclic natural product and a purported transit...

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Bibliografiset tiedot
Päätekijät: Tantravedi, Saritha, Chakraborty, Saibal, Shah, Niti H., Fishbein, James C., Hosmane, Ramachandra S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761942/
https://ncbi.nlm.nih.gov/pubmed/23891230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.06.069
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