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Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively Substituted Imidazo[4,5-e][1,4]diazepines

Guanase is an important enzyme of the purine salvage pathway of nucleic acid metabolism and its inhibition has beneficial implications in viral, bacterial, and cancer therapy. The work described herein is based on a hypothesis that azepinomycin, a heterocyclic natural product and a purported transit...

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Bibliografische gegevens
Hoofdauteurs: Tantravedi, Saritha, Chakraborty, Saibal, Shah, Niti H., Fishbein, James C., Hosmane, Ramachandra S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761942/
https://ncbi.nlm.nih.gov/pubmed/23891230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.06.069
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