Characterization of Imidazo[4,5-d]Pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus Nucleoside Triphosphatase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme

Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated b...

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Detalhes bibliográficos
Main Authors: Borowski, Peter, Lang, Melanie, Haag, Annemarie, Schmitz, Herbert, Choe, Joonho, Chen, Huan-Ming, Hosmane, Ramachandra S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127168/
https://ncbi.nlm.nih.gov/pubmed/11959550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1231-1239.2002
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