Characterization of Imidazo[4,5-d]Pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus Nucleoside Triphosphatase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme

Compounds that interact with DNA or RNA generally act as inhibitors of enzymes that unwind DNA or RNA. In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated b...

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Argitaratua izan da:	Antimicrob Agents Chemother
Egile Nagusiak:	Borowski, Peter, Lang, Melanie, Haag, Annemarie, Schmitz, Herbert, Choe, Joonho, Chen, Huan-Ming, Hosmane, Ramachandra S.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2002
Gaiak:	Antiviral Agents
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127168/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1231-1239.2002
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