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Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity

The attempted removal of the aralkyl group of 2-bromo-1-p-methoxybenzyl-6-octylimidazo[4,5-e][1,3]diazepine (ZP-33) with trifluoroacetic acid resulted in replacement of the bromo group with a carbonyl at position-2 in addition to the desired deprotection at the 1-position. 2′-Deoxynucleosides of 2-b...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Peng, Zhang, Ning, Buckwold, Victor E., Hosmane, Ramachandra S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754285/
https://ncbi.nlm.nih.gov/pubmed/17507230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.04.043
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