Chemistry of the Cysteine Sensors in Kelch-Like ECH-Associated Protein 1

Por Holland, Ryan, Fishbein, James C.
Publicado em 2010

Decoding Nitric Oxide Release Rates of Amine-Based Diazeniumdiolates

Por Wang, Yan-Ni, Collins, Jack, Holland, Ryan J., Keefer, Larry K., Ivanic, Joseph
Publicado em 2013

Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones

Por Holland, Ryan, Navamal, Mettachit, Velayutham, Murugesan, Zweier, Jay L., Kensler, Thomas W., Fishbein, James C.
Publicado em 2009

Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase

Por Holland, Ryan J., Paulisch, Rika, Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E., Donzelli, Sonia
Publicado em 2013

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

Por Holland, Ryan, Hawkins, Arie E., Eggler, Aimee L., Mesecar, Andrew D., Fabris, Daniele, Fishbein, James C.
Publicado no Chem Res Toxicol (2008)

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

Por Kumari, Vandana, Dyba, Marzena A., Holland, Ryan J., Liang, Yu-He, Singh, Shivendra V., Ji, Xinhua
Publicado no PLoS One (2016)

Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class

Por Maciag, Anna E., Holland, Ryan J., Saavedra, Joseph E., Chakrapani, Harinath, Shami, Paul J., Keefer, Larry K.
Publicado em 2012

Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

Por Holland, Ryan J., Klose, John R., Deschamps, Jeffrey R., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2014

Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

Por Biswas, Debanjan, Hrabie, Joseph A., Saavedra, Joseph E., Cao, Zhao, Keefer, Larry K., Ivanic, Joseph, Holland, Ryan J.
Publicado em 2014

‘Click’ Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors

Por Oladeinde, Oyebola A., Hong, Sam Y., Holland, Ryan J., Maciag, Anna E., Keefer, Larry K., Saavedra, Joseph E., Nandurdikar, Rahul S.
Publicado em 2010

Cobalt 1,3-Diisopropyl-1H-imidazol-2-ylidene Complexes: Synthesis, Solid-State Structures, and Quantum Chemistry Calculations

Por Vélez, Carmen L., Markwick, Phineus R. L., Holland, Ryan L., DiPasquale, Antonio G., Rheingold, Arnold L., O’Connor, Joseph M.
Publicado em 2010

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance()

Por Maciag, Anna E., Holland, Ryan J., Robert Cheng, Y.-S., Rodriguez, Luis G., Saavedra, Joseph E., Anderson, Lucy M., Keefer, Larry K.
Publicado em 2013

Crosslinking Protein Glutathionylation Mediated by O(2)-Arylated Bis-Diazeniumdiolate “Double JS-K”

Por Holland, Ryan J., Maciag, Anna E., Kumar, Varun, Shi, Lei, Saavedra, Joseph E., Prud’homme, Robert K., Chakrapani, Harinath, Keefer, Larry K.
Publicado em 2012

Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

Por Nandurdikar, Rahul S., Maciag, Anna E., Holland, Ryan J., Cao, Zhao, Shami, Paul J., Anderson, Lucy M., Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2012

The Nitric Oxide Prodrug JS-K Is Effective against Non–Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species

Por Maciag, Anna E., Chakrapani, Harinath, Saavedra, Joseph E., Morris, Nicole L., Holland, Ryan J., Kosak, Ken M., Shami, Paul J., Anderson, Lucy M., Keefer, Larry K.
Publicado em 2011

Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells

Por Kaczmarek, Monika Z., Holland, Ryan J., Lavanier, Stephen A., Troxler, Jami A., Fesenkova, Valentyna I., Hanson, Charlotte A., Cmarik, Joan L., Saavedra, Joseph E., Keefer, Larry K., Ruscetti, Sandra K.
Publicado em 2013

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

Por Maciag, Anna E., Holland, Ryan J., Kim, Youseung, Kumari, Vandana, Luthers, Christina E., Sehareen, Waheed S., Biswas, Debanjan, Morris, Nicole L., Ji, Xinhua, Anderson, Lucy M., Saavedra, Joseph E., Keefer, Larry K.
Publicado em 2014

Synthesis and Chemical and Biological Comparison of Nitroxyl and Nitric Oxide Releasing Diazeniumdiolate-based Aspirin Derivatives

Por Basudhar, Debashree, Bharadwaj, Gaurav, Cheng, Robert Y., Jain, Sarthak, Shi, Sa, Heinecke, Julie L., Holland, Ryan J., Ridnour, Lisa A., Caceres, Viviane M., Spadari-Bratfisch, Regina C., Paolocci, Nazareno, Velázquez-Martínez, Carlos A., Wink, David A., Miranda, Katrina M.
Publicado em 2013