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Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones

The ability of three dithiolethione cancer chemopreventives - oltipraz 1, anetholedithione (ADT) 2, 1,2-dithiole-3-thione (D3T) 3 and the major metabolite, 4, of 1 - to induce the cytoprotective enzyme NQO1 in hepa 1c1c7 cells and the inhibition of this induction by catalase is demonstrated. The abi...

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Hlavní autoři: Holland, Ryan, Navamal, Mettachit, Velayutham, Murugesan, Zweier, Jay L., Kensler, Thomas W., Fishbein, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755628/
https://ncbi.nlm.nih.gov/pubmed/19785463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900110n
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