Synthesis and Chemical and Biological Comparison of Nitroxyl and Nitric Oxide Releasing Diazeniumdiolate-based Aspirin Derivatives

Structural modifications of non-steroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity, but may increase risk of myocardial infarction with chronic use. That nitroxyl (HNO) reduces platelet aggr...

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Hlavní autoři: Basudhar, Debashree, Bharadwaj, Gaurav, Cheng, Robert Y., Jain, Sarthak, Shi, Sa, Heinecke, Julie L., Holland, Ryan J., Ridnour, Lisa A., Caceres, Viviane M., Spadari-Bratfisch, Regina C., Paolocci, Nazareno, Velázquez-Martínez, Carlos A., Wink, David A., Miranda, Katrina M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880621/
https://ncbi.nlm.nih.gov/pubmed/24102516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400196q
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