Regulation of mitochondrial genome replication by hypoxia: the role of DNA oxidation in D-loop region

gan Pastukh, Viktor M., Gorodnya, Olena M., Gillespie, Mark N., Ruchko, Mykhaylo V.
Cyhoeddwyd yn Free Radic Biol Med (2016)

The DNA Glycosylase, Ogg1, Defends Against Oxidant-induced mtDNA Damage and Apoptosis in Pulmonary Artery Endothelial Cells

gan Ruchko, Mykhaylo V., Gorodnya, Olena M., Zuleta, Andres, Pastukh, Viktor M., Gillespie, Mark N.
Cyhoeddwyd 2010

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

gan Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N
Cyhoeddwyd 2011

HYPOXIA-INDUCED OXIDATIVE BASE MODIFICATIONS IN THE VEGF HYPOXIC RESPONSE ELEMENT ARE ASSOCIATED WITH TRANSCRIPTIONALLY ACTIVE NUCLEOSOMES

gan Ruchko, Mykhaylo V., Gorodnya, Olena M., Pastukh, Viktor M., Swiger, Brad M., Middleton, Natavia S., Wilson, Glenn L., Gillespie, Mark N.
Cyhoeddwyd 2008

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs

gan Kuck, Jamie L., Obiako, Boniface O., Gorodnya, Olena M., Pastukh, Viktor M., Kua, Justin, Simmons, Jon D., Gillespie, Mark N.
Cyhoeddwyd yn Am J Physiol Lung Cell Mol Physiol (2015)

Pharmacologic Protection of Mitochondrial DNA Integrity May Afford a New Strategy for Suppressing Lung Ischemia-Reperfusion Injury

gan Tan, Yong B., Mulekar, Sujata, Gorodnya, Olena, Weyant, Michael J., Zamora, Martin R., Simmons, Jon D., Machuka, Tiago, Gillespie, Mark N.
Cyhoeddwyd yn Ann Am Thorac Soc (2017)

Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice

gan Hashizume, Masahiro, Mouner, Marc, Chouteau, Joshua M., Gorodnya, Olena M., Ruchko, Mykhaylo V., Wilson, Glenn L., Gillespie, Mark N., Parker, James C.
Cyhoeddwyd 2014

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs

gan Chouteau, Joshua M., Obiako, Boniface, Gorodnya, Olena M., Pastukh, Viktor M., Ruchko, Mykhaylo V., Wright, Anthony J., Wilson, Glenn L., Gillespie, Mark N.
Cyhoeddwyd 2011

Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice

gan Hashizume, Masahiro, Mouner, Marc, Chouteau, Joshua M., Gorodnya, Olena M., Ruchko, Mykhaylo V., Potter, Barry J., Wilson, Glenn L., Gillespie, Mark N., Parker, James C.
Cyhoeddwyd 2013

Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-tracheal Pseudomonas aeruginosa

gan Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M., Ruchko, Mykhaylo V., Kuck, Jamie L., Pastukh, Viktor M., Wilson, Glenn L., Simmons, Jon D., Gillespie, Mark N.
Cyhoeddwyd yn Shock (2017)

Enhanced mtDNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death

gan Tan, Yong B., Pastukh, Viktor M., Gorodnya, Olena M., Mulekar, Madhuri S., Simmons, Jon D., Machuca, Tiago N., Beaver, Thomas M., Wilson, Glenn L., Gillespie, Mark N.
Cyhoeddwyd yn J Surg Res (2019)

Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Pro...

gan Black, George Edward, Sokol, Kyle K., Moe, Donald M., Simmons, Jon D., Muscat, David, Pastukh, Victor, Capley, Gina, Gorodnya, Olena, Ruchko, Mykhaylo, Roth, Mark B., Gillespie, Mark, Martin, Matthew J.
Cyhoeddwyd yn J Trauma Acute Care Surg (2017)

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure

gan Bradley, Jessica M., Li, Zhen, Organ, Chelsea L., Polhemus, David J., Otsuka, Hiroyuki, Islam, Kazi N., Bhushan, Shashi, Gorodnya, Olena M., Ruchko, Mykhaylo V., Gillespie, Mark N., Wilson, Glenn L., Lefer, David J.
Cyhoeddwyd yn Am J Physiol Heart Circ Physiol (2018)