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Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

Lung tissue from COPD patients displays oxidative DNA damage. The present study determined whether oxidative DNA damage was randomly distributed or whether it was localized in specific sequences in either the nuclear or mitochondrial genomes. The DNA damage-specific histone, gamma-H2AX, was detected...

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Bibliografiske detaljer
Main Authors: Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107697/
https://ncbi.nlm.nih.gov/pubmed/21660298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S15922
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