HYPOXIA-INDUCED OXIDATIVE BASE MODIFICATIONS IN THE VEGF HYPOXIC RESPONSE ELEMENT ARE ASSOCIATED WITH TRANSCRIPTIONALLY ACTIVE NUCLEOSOMES

Reactive oxygen species (ROS) generated in hypoxic pulmonary artery endothelial cells cause transient oxidative base modifications in the hypoxic response element (HRE) of the VEGF gene that bear a conspicuous relationship to induction of VEGF mRNA expression (FASEB J 19: 387-394, 2005). If such bas...

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Autori principali: Ruchko, Mykhaylo V., Gorodnya, Olena M., Pastukh, Viktor M., Swiger, Brad M., Middleton, Natavia S., Wilson, Glenn L., Gillespie, Mark N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645035/
https://ncbi.nlm.nih.gov/pubmed/18992807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.09.038
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