Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs

In cultured pulmonary artery endothelial cells and other cell types, overexpression of mt-targeted DNA repair enzymes protects against oxidant-induced mitochondrial DNA (mtDNA) damage and cell death. Whether mtDNA integrity governs functional properties of the endothelium in the intact pulmonary cir...

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Autors principals: Chouteau, Joshua M., Obiako, Boniface, Gorodnya, Olena M., Pastukh, Viktor M., Ruchko, Mykhaylo V., Wright, Anthony J., Wilson, Glenn L., Gillespie, Mark N.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233824/
https://ncbi.nlm.nih.gov/pubmed/21890512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00210.2011
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