Controlled DNA “Damage” and Repair in Hypoxic Signaling

Por Gillespie, Mark N., Pastukh, Viktor M., Ruchko, Mykhaylo V.
Publicado em 2010

Regulation of mitochondrial genome replication by hypoxia: the role of DNA oxidation in D-loop region

Por Pastukh, Viktor M., Gorodnya, Olena M., Gillespie, Mark N., Ruchko, Mykhaylo V.
Publicado no Free Radic Biol Med (2016)

The DNA Glycosylase, Ogg1, Defends Against Oxidant-induced mtDNA Damage and Apoptosis in Pulmonary Artery Endothelial Cells

Por Ruchko, Mykhaylo V., Gorodnya, Olena M., Zuleta, Andres, Pastukh, Viktor M., Gillespie, Mark N.
Publicado em 2010

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

Por Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N
Publicado em 2011

HYPOXIA-INDUCED OXIDATIVE BASE MODIFICATIONS IN THE VEGF HYPOXIC RESPONSE ELEMENT ARE ASSOCIATED WITH TRANSCRIPTIONALLY ACTIVE NUCLEOSOMES

Por Ruchko, Mykhaylo V., Gorodnya, Olena M., Pastukh, Viktor M., Swiger, Brad M., Middleton, Natavia S., Wilson, Glenn L., Gillespie, Mark N.
Publicado em 2008

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs

Por Kuck, Jamie L., Obiako, Boniface O., Gorodnya, Olena M., Pastukh, Viktor M., Kua, Justin, Simmons, Jon D., Gillespie, Mark N.
Publicado no Am J Physiol Lung Cell Mol Physiol (2015)

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs

Por Chouteau, Joshua M., Obiako, Boniface, Gorodnya, Olena M., Pastukh, Viktor M., Ruchko, Mykhaylo V., Wright, Anthony J., Wilson, Glenn L., Gillespie, Mark N.
Publicado em 2011

Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-tracheal Pseudomonas aeruginosa

Por Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M., Ruchko, Mykhaylo V., Kuck, Jamie L., Pastukh, Viktor M., Wilson, Glenn L., Simmons, Jon D., Gillespie, Mark N.
Publicado no Shock (2017)

Potential contribution of mitochondrial (mt) DNA damage associated molecular patterns (DAMPs) in transfusion products to the development of acute respiratory distress syndrome (ARD...

Por Simmons, Jon D., Lee, Yann-leei L., Pastukh, Viktor M., Capley, Gina, Muscat, Cherry A., Muscat, David C., Marshall, Michael L., Brevard, Sidney B., Gillespie, Mark N.
Publicado no J Trauma Acute Care Surg (2017)

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Por Al-Mehdi, Abu-Bakr, Pastukh, Viktor M., Swiger, Brad M., Reed, Darla J., Patel, Mita R., Bardwell, Gina C., Pastukh, Viktoriya V., Alexeyev, Mikhail F., Gillespie, Mark N.
Publicado em 2012