Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Mitochondria can govern local concentrations of second messengers, such as reactive oxygen species (ROS), and mitochondrial translocation to discrete subcellular regions may contribute to this signaling function. Here, we report that exposure of pulmonary artery endothelial cells to hypoxia triggere...

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Autores principales: Al-Mehdi, Abu-Bakr, Pastukh, Viktor M., Swiger, Brad M., Reed, Darla J., Patel, Mita R., Bardwell, Gina C., Pastukh, Viktoriya V., Alexeyev, Mikhail F., Gillespie, Mark N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565837/
https://ncbi.nlm.nih.gov/pubmed/22763339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002712
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