Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Eitemau Tebyg

• An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression
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  Cyhoeddwyd: (2015)
• HYPOXIA-INDUCED OXIDATIVE BASE MODIFICATIONS IN THE VEGF HYPOXIC RESPONSE ELEMENT ARE ASSOCIATED WITH TRANSCRIPTIONALLY ACTIVE NUCLEOSOMES
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• Increased Depth of Cellular Imaging in the Intact Lung Using Far-Red and Near-Infrared Fluorescent Probes
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• A retro-lentiviral system for doxycycline-inducible gene expression and gene knockdown in cells with limited proliferative capacity
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  Cyhoeddwyd: (2009)
• Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences
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  Cyhoeddwyd: (2011)