Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Mitochondria can govern local concentrations of second messengers, such as reactive oxygen species (ROS), and mitochondrial translocation to discrete subcellular regions may contribute to this signaling function. Here, we report that exposure of pulmonary artery endothelial cells to hypoxia triggere...

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Detalhes bibliográficos
Main Authors: Al-Mehdi, Abu-Bakr, Pastukh, Viktor M., Swiger, Brad M., Reed, Darla J., Patel, Mita R., Bardwell, Gina C., Pastukh, Viktoriya V., Alexeyev, Mikhail F., Gillespie, Mark N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565837/
https://ncbi.nlm.nih.gov/pubmed/22763339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002712
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