Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs

Por Kuck, Jamie L., Obiako, Boniface O., Gorodnya, Olena M., Pastukh, Viktor M., Kua, Justin, Simmons, Jon D., Gillespie, Mark N.
Publicado no Am J Physiol Lung Cell Mol Physiol (2015)

Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin

Por Kuck, Jamie L., Bastarache, Julie A., Shaver, Ciara M., Fessel, Joshua P., Dikalov, Sergey I., May, James M., Ware, Lorraine B.
Publicado no Biochem Biophys Res Commun (2017)

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

Por Simmon, Jon D., Lee, Yann-Leei, Mulekar, Sujata, Kuck, Jamie L., Brevard, Sidney B., Gonzalez, Richard P., Gillespie, Mark N., Richards, William O.
Publicado em 2013

Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target

Por Shaver, Ciara M., Wickersham, Nancy, McNeil, J. Brennan, Nagata, Hiromasa, Sills, Gillian, Kuck, Jamie L., Janz, David R., Bastarache, Julie A., Ware, Lorraine B.
Publicado no Ann Am Thorac Soc (2017)

Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-tracheal Pseudomonas aeruginosa

Por Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M., Ruchko, Mykhaylo V., Kuck, Jamie L., Pastukh, Viktor M., Wilson, Glenn L., Simmons, Jon D., Gillespie, Mark N.
Publicado no Shock (2017)

Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury

Por Shaver, Ciara M., Wickersham, Nancy, McNeil, J. Brennan, Nagata, Hiromasa, Miller, Adam, Landstreet, Stuart R., Kuck, Jamie L., Diamond, Joshua M., Lederer, David J., Kawut, Steven M., Palmer, Scott M., Wille, Keith M., Weinacker, Ann, Lama, Vibha N., Crespo, Maria M., Orens, Jonathan B., Shah, Pali D., Hage, Chadi A., Cantu, Edward, Porteous, Mary K., Dhillon, Gundeep, McDyer, John, Bastarache, Julie A., Christie, Jason D., Ware, Lorraine B.
Publicado no JCI Insight (2018)