Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice

This study tested the hypothesis that oxidative mitochondrial-targeted DNA (mtDNA) damage triggered ventilator-induced lung injury (VILI). Control mice and mice infused with a fusion protein targeting the DNA repair enzyme, 8-oxoguanine-DNA glycosylase 1 (OGG1) to mitochondria were mechanically vent...

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Detalhes bibliográficos
Main Authors: Hashizume, Masahiro, Mouner, Marc, Chouteau, Joshua M., Gorodnya, Olena M., Ruchko, Mykhaylo V., Potter, Barry J., Wilson, Glenn L., Gillespie, Mark N., Parker, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567361/
https://ncbi.nlm.nih.gov/pubmed/23241530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00071.2012
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