Thermodynamics of the DNA Damage Repair Steps of Human 8-Oxoguanine DNA Glycosylase

Human 8-oxoguanine DNA glycosylase (hOGG1) is a key enzyme responsible for initiating the base excision repair of 7,8-dihydro-8-oxoguanosine (oxoG). In this study a thermodynamic analysis of the interaction of hOGG1 with specific and non-specific DNA-substrates is performed based on stopped-flow kin...

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Autores principales: Kuznetsov, Nikita A., Kuznetsova, Alexandra A., Vorobjev, Yuri N., Krasnoperov, Lev N., Fedorova, Olga S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049573/
https://ncbi.nlm.nih.gov/pubmed/24911585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098495
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