Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase

We have used a stepwise increase in ligand complexity approach to estimate the relative contributions of the nucleotide units of DNA containing 7,8-dihydro-8-oxoguanine (oxoG) to its total affinity for human 8-oxoguanine DNA glycosylase (OGG1) and construct thermodynamic models of the enzyme interac...

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Bibliographische Detailangaben
Hauptverfasser: Kirpota, Oleg O., Endutkin, Anton V., Ponomarenko, Michail P., Ponomarenko, Petr M., Zharkov, Dmitry O., Nevinsky, Georgy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113562/
https://ncbi.nlm.nih.gov/pubmed/21343179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1333
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