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DNA deformation-coupled recognition of 8-oxoguanine: conformational kinetic gating in human DNA glycosylase
8-Oxoguanine (8-oxoG), a mutagenic DNA lesion generated under oxidative stress, differs from its precursor guanine by only two substitutions (O(8) andH(7)). Human 8-oxoguanine glycosylase 1 (OGG1) can locate and remove 8-oxoG through extrusion and excision. To date, it remains unclear how OGG1 effic...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321822/ https://ncbi.nlm.nih.gov/pubmed/28098999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11433 |
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