DNA deformation-coupled recognition of 8-oxoguanine: conformational kinetic gating in human DNA glycosylase

8-Oxoguanine (8-oxoG), a mutagenic DNA lesion generated under oxidative stress, differs from its precursor guanine by only two substitutions (O(8) andH(7)). Human 8-oxoguanine glycosylase 1 (OGG1) can locate and remove 8-oxoG through extrusion and excision. To date, it remains unclear how OGG1 effic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Li, Haoquan, Endutkin, Anton V., Bergonzo, Christina, Fu, Lin, Grollman, Arthur, Zharkov, Dmitry O., Simmerling, Carlos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321822/
https://ncbi.nlm.nih.gov/pubmed/28098999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11433
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