A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine–DNA glycosylase

In contrast to proteins recognizing small-molecule ligands, DNA-dependent enzymes cannot rely solely on interactions in the substrate-binding centre to achieve their exquisite specificity. It is widely believed that substrate recognition by such enzymes involves a series of conformational changes in...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Li, Haoquan, Endutkin, Anton V., Bergonzo, Christina, Campbell, Arthur J., de los Santos, Carlos, Grollman, Arthur, Zharkov, Dmitry O., Simmerling, Carlos
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737139/
https://ncbi.nlm.nih.gov/pubmed/26553802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1092
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