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A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine–DNA glycosylase
In contrast to proteins recognizing small-molecule ligands, DNA-dependent enzymes cannot rely solely on interactions in the substrate-binding centre to achieve their exquisite specificity. It is widely believed that substrate recognition by such enzymes involves a series of conformational changes in...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737139/ https://ncbi.nlm.nih.gov/pubmed/26553802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1092 |
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