Molecular dynamics simulation of the opposite-base preference and interactions in the active site of formamidopyrimidine-DNA glycosylase

BACKGROUND: Formamidopyrimidine-DNA glycosylase (Fpg) removes abundant pre-mutagenic 8-oxoguanine (oxoG) bases from DNA through nucleophilic attack of its N-terminal proline at C1′ of the damaged nucleotide. Since oxoG efficiently pairs with both C and A, Fpg must excise oxoG from pairs with C but n...

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Detaylı Bibliyografya
Yayımlandı:BMC Struct Biol
Asıl Yazarlar: Popov, Alexander V., Endutkin, Anton V., Vorobjev, Yuri N., Zharkov, Dmitry O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422863/
https://ncbi.nlm.nih.gov/pubmed/28482831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-017-0075-y
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