Molecular dynamics simulation of the opposite-base preference and interactions in the active site of formamidopyrimidine-DNA glycosylase

BACKGROUND: Formamidopyrimidine-DNA glycosylase (Fpg) removes abundant pre-mutagenic 8-oxoguanine (oxoG) bases from DNA through nucleophilic attack of its N-terminal proline at C1′ of the damaged nucleotide. Since oxoG efficiently pairs with both C and A, Fpg must excise oxoG from pairs with C but n...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Struct Biol
Egile Nagusiak: Popov, Alexander V., Endutkin, Anton V., Vorobjev, Yuri N., Zharkov, Dmitry O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422863/
https://ncbi.nlm.nih.gov/pubmed/28482831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-017-0075-y
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