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Computational analysis of the binding mode of 8-oxo-guanine to formamidopyrimidine-DNA glycosylase
8-oxo-guanine (8OG) is the most prevalent form of oxidative DNA damage. In bacteria, 8OG is excised by formamidopyrimidine glycosylase (Fpg) as the initial step in base excision repair. To efficiently excise this lesion, Fpg must discriminate between 8OG and an excess of guanine in duplex DNA. In th...
Tallennettuna:
| Julkaisussa: | Biochemistry |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2006
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8295719/ https://ncbi.nlm.nih.gov/pubmed/16953574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060380m |
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