Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition

Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxoguanine (oxoG) from DNA but ignores normal guanine. We combined molecular dynamics simulation and stopped-flow kinetics with fluorescence detection to track the events in the recognition of oxoG by Fpg and its mutants with a key phenylalanine re...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kuznetsov, Nikita A., Bergonzo, Christina, Campbell, Arthur J., Li, Haoquan, Mechetin, Grigory V., de los Santos, Carlos, Grollman, Arthur P., Fedorova, Olga S., Zharkov, Dmitry O., Simmerling, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288190/
https://ncbi.nlm.nih.gov/pubmed/25520195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1300
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