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Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase
Human 8-oxoguanine-DNA glycosylase (hOgg1) excises 8-oxo-7,8-dihydroguanine (8-oxoG) from damaged DNA. We report a pre-steady-state kinetic analysis of hOgg1 mechanism using stopped-flow and enzyme fluorescence monitoring. The kinetic scheme for hOgg1 processing an 8-oxoG:C-containing substrate was...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2005
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1176011/ https://ncbi.nlm.nih.gov/pubmed/16024742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki694 |
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