Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase

Human 8-oxoguanine-DNA glycosylase (hOgg1) excises 8-oxo-7,8-dihydroguanine (8-oxoG) from damaged DNA. We report a pre-steady-state kinetic analysis of hOgg1 mechanism using stopped-flow and enzyme fluorescence monitoring. The kinetic scheme for hOgg1 processing an 8-oxoG:C-containing substrate was...

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Bibliografske podrobnosti
Main Authors: Kuznetsov, Nikita A., Koval, Vladimir V., Zharkov, Dmitry O., Nevinsky, Georgy A., Douglas, Kenneth T., Fedorova, Olga S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2005
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176011/
https://ncbi.nlm.nih.gov/pubmed/16024742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki694
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