Thermodynamics of the multi-stage DNA lesion recognition and repair by formamidopyrimidine-DNA glycosylase using pyrrolocytosine fluorescence—stopped-flow pre-steady-state kinetics

Formamidopyrimidine-DNA glycosylase, Fpg protein from Escherichia coli, initiates base excision repair in DNA by removing a wide variety of oxidized lesions. In this study, we perform thermodynamic analysis of the multi-stage interaction of Fpg with specific DNA-substrates containing 7,8-dihydro-8-o...

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Bibliographic Details
Main Authors: Kuznetsov, Nikita A., Vorobjev, Yuri N., Krasnoperov, Lev N., Fedorova, Olga S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424566/
https://ncbi.nlm.nih.gov/pubmed/22584623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks423
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