Deep mutational scanning: a new style of protein science

av Fowler, Douglas M., Fields, Stanley
I publikationen Nat Methods (2014)

Deep mutational scanning: assessing protein function on a massive scale

av Araya, Carlos L., Fowler, Douglas M.
Publicerad 2011

Functional Amyloidogenesis and Cytotoxicity—Insights into Biology and Pathology

av Fowler, Douglas M., Kelly, Jeffery W.
Publicerad 2012

Contemporary, yeast-based approaches to understanding human genetic variation

av Dunham, Maitreya J., Fowler, Douglas M.
Publicerad 2013

Keeping up with the genomes: scaling genomic variant interpretation

av Rehm, Heidi L., Fowler, Douglas M.
I publikationen Genome Med (2019)

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

av Taskinen, Barbara, Ferrada, Evandro, Fowler, Douglas M.
I publikationen J Biol Chem (2017)

Measuring the activity of protein variants on a large scale using deep mutational scanning

av Fowler, Douglas M., Stephany, Jason J., Fields, Stanley
I publikationen Nat Protoc (2014)

The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes

av Hasle, Nicholas, Matreyek, Kenneth A., Fowler, Douglas M.
I publikationen Cold Spring Harb Perspect Med (2019)

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

av Chen, John Z, Fowler, Douglas M, Tokuriki, Nobuhiko
I publikationen eLife (2020)

Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis

av Mu, Ting-Wei, Fowler, Douglas M, Kelly, Jeffery W
Publicerad 2008

A platform for functional assessment of large variant libraries in mammalian cells

av Matreyek, Kenneth A., Stephany, Jason J., Fowler, Douglas M.
I publikationen Nucleic Acids Res (2017)

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions

av Gray, Vanessa E., Hause, Ronald J., Fowler, Douglas M.
I publikationen Genetics (2017)

Enrich: software for analysis of protein function by enrichment and depletion of variants

av Fowler, Douglas M., Araya, Carlos L., Gerard, Wayne, Fields, Stanley
Publicerad 2011

Biophysical and Mechanistic models for disease-causing protein variants

av Stein, Amelie, Fowler, Douglas M., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten
I publikationen Trends Biochem Sci (2019)

Applying multiplex assays to understand variation in pharmacogenes

av Chiasson, Melissa, Dunham, Maitreya J., Rettie, Allan E., Fowler, Douglas M.
I publikationen Clin Pharmacol Ther (2019)

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations(†)

av Daly, Ann K., Rettie, Allan E., Fowler, Douglas M., Miners, John O.
I publikationen J Pers Med (2017)

Quantitative missense variant effect prediction using large-scale mutagenesis data

av Gray, Vanessa E., Hause, Ronald J., Luebeck, Jens, Shendure, Jay, Fowler, Douglas M.
I publikationen Cell Syst (2017)

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

av Rose, John C., Stephany, Jason J., Wei, Cindy T., Fowler, Douglas M., Maly, Dustin J.
I publikationen ACS Chem Biol (2017)

An improved platform for functional assessment of large protein libraries in mammalian cells

av Matreyek, Kenneth A, Stephany, Jason J, Chiasson, Melissa A, Hasle, Nicholas, Fowler, Douglas M
I publikationen Nucleic Acids Res (2020)

Suppression of statin effectiveness by copper and zinc in yeast and human cells

av Fowler, Douglas M., Cooper, Sara J., Stephany, Jason J., Hendon, Natalie, Nelson, Sven, Fields, Stanley
Publicerad 2010