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Biophysical and Mechanistic models for disease-causing protein variants

The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In medicine, genome sequencing has revealed millions of missense variants that change protein sequences, yet we only understand the molecular and phenotypic consequences of a small fraction. Within protein science, hi...

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Publicat a:Trends Biochem Sci
Autors principals: Stein, Amelie, Fowler, Douglas M., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579676/
https://ncbi.nlm.nih.gov/pubmed/30712981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2019.01.003
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