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Biophysical and Mechanistic models for disease-causing protein variants

The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In medicine, genome sequencing has revealed millions of missense variants that change protein sequences, yet we only understand the molecular and phenotypic consequences of a small fraction. Within protein science, hi...

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Detalhes bibliográficos
Publicado no:Trends Biochem Sci
Main Authors: Stein, Amelie, Fowler, Douglas M., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579676/
https://ncbi.nlm.nih.gov/pubmed/30712981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2019.01.003
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