Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

Understanding and predicting how amino acid substitutions affect proteins are keys to our basic understanding of protein function and evolution. Amino acid changes may affect protein function in a number of ways including direct perturbations of activity or indirect effects on protein folding and st...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Cagiada, Matteo, Johansson, Kristoffer E, Valanciute, Audrone, Nielsen, Sofie V, Hartmann-Petersen, Rasmus, Yang, Jun J, Fowler, Douglas M, Stein, Amelie, Lindorff-Larsen, Kresten
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321532/
https://ncbi.nlm.nih.gov/pubmed/33779753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msab095
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