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Deep mutational scanning: a new style of protein science

Mutagenesis provides insight into proteins, but only recently have assays that couple genotype to phenotype been used to assess the activities of as many as a million mutant versions of a protein in a single experiment. This approach – “deep mutational scanning” – yields large-scale datasets that ca...

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書目詳細資料
發表在:Nat Methods
Main Authors: Fowler, Douglas M., Fields, Stanley
格式: Artigo
語言:Inglês
出版: 2014
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410700/
https://ncbi.nlm.nih.gov/pubmed/25075907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3027
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