A statistical framework for analyzing deep mutational scanning data

Deep mutational scanning is a widely used method for multiplex measurement of functional consequences of protein variants. We developed a new deep mutational scanning statistical model that generates error estimates for each measurement, capturing both sampling error and consistency between replicat...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Rubin, Alan F., Gelman, Hannah, Lucas, Nathan, Bajjalieh, Sandra M., Papenfuss, Anthony T., Speed, Terence P., Fowler, Douglas M.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Method
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547491/
https://ncbi.nlm.nih.gov/pubmed/28784151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1272-5
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