Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity

Por Flaveny, Colin A., Perdew, Gary H.
Publicado em 2009

The Aryl-hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo

Por Flaveny, Colin, Perdew, Gary H., Miller, Charles A.
Publicado em 2009

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Por Flaveny, Colin A., Murray, Iain A., Perdew, Gary H.
Publicado em 2010

The mouse and human Ah receptor differ in recognition of LXXLL motifs

Por Flaveny, Colin, Reen, Rashmeet K., Kusnadi, Ann, Perdew, Gary H.
Publicado em 2008

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Por Flaveny, Colin A., Murray, Iain A., Chiaro, Chris R., Perdew, Gary H.
Publicado em 2009

Ah receptor represses acute phase response gene expression without binding to its cognate response element

Por Patel, Rushang D., Murray, Iain A., Flaveny, Colin A., Kusnadi, Ann, Perdew, Gary H.
Publicado em 2009

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Por Griffett, Kristine, Welch, Ryan D., Flaveny, Colin A., Kolar, Grant R., Neuschwander-Tetri, Brent A., Burris, Thomas P.
Publicado no Mol Metab (2015)

Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone

Por Murray, Iain A., Flaveny, Colin A., DiNatale, Brett C., Chairo, Chris R., Schroeder, Jennifer C., Kusnadi, Ann, Perdew, Gary H.
Publicado em 2010

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Por Murray, Iain A., Morales, Jose L., Flaveny, Colin A., DiNatale, Brett C., Chiaro, Chris, Gowdahalli, Krishnegowda, Amin, Shantu, Perdew, Gary H.
Publicado em 2010

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Por DiNatale, Brett C., Murray, Iain A., Schroeder, Jennifer C., Flaveny, Colin A., Lahoti, Tejas S., Laurenzana, Elizabeth M., Omiecinski, Curtis J., Perdew, Gary H.
Publicado em 2010

Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties

Por Murray, Iain A., Krishnegowda, Gowdahalli, DiNatale, Brett C., Flaveny, Colin, Chiaro, Chris, Lin, Jyh-Ming, Sharma, Arun K., Amin, Shantu, Perdew, Gary H.
Publicado em 2010

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Por Schaub, Franz X, Reza, Md Shamim, Flaveny, Colin A, Li, Weimin, Musicant, Adele M, Hoxha, Sany, Guo, Min, Cleveland, John L, Amelio, Antonio L
Publicado no Cancer Res (2015)

Suppression of Cytokine-Mediated Complement Factor Gene Expression through Selective Activation of the Ah Receptor with 3′,4′-Dimethoxy-α-naphthoflavone

Por Murray, Iain A., Flaveny, Colin A., Chiaro, Christopher R., Sharma, Arun K., Tanos, Rachel S., Schroeder, Jennifer C., Amin, Shantu G., Bisson, William H., Kolluri, Siva K., Perdew, Gary H.
Publicado em 2011

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Por Flaveny, Colin A., Griffett, Kristine, El-Gendy, Bahaa El-Dien M., Kazantzis, Melissa, Sengupta, Monideepa, Amelio, Antonio L., Chatterjee, Arindam, Walker, John, Solt, Laura A., Kamenecka, Theodore M., Burris, Thomas P.
Publicado no Cancer Cell (2015)

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Por Schroeder, Jennifer C., DiNatale, Brett C., Murray, Iain A., Flaveny, Colin A., Liu, Qiang, Laurenzana, Elizabeth M., Lin, Jyh Ming, Strom, Stephen C., Omiecinski, Curtis J., Amin, Shantu, Perdew, Gary H.
Publicado em 2010

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Por Boitano, Anthony E., Wang, Jian, Romeo, Russell, Bouchez, Laure C., Parker, Albert E., Sutton, Sue E., Walker, John R., Flaveny, Colin A., Perdew, Gary H., Denison, Michael S., Schultz, Peter G., Cooke, Michael P.
Publicado em 2010

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

Por Li, Bin, Flaveny, Colin A., Giambelli, Camilla, Fei, Dennis Liang, Han, Lu, Hang, Brian I., Bai, Feng, Pei, Xin-Hai, Nose, Vania, Burlingame, Oname, Capobianco, Anthony J., Orton, Darren, Lee, Ethan, Robbins, David J.
Publicado em 2014

Pyrvinium attenuates Hedgehog signaling downstream of Smoothened

Por Li, Bin, Fei, Dennis Liang, Flaveny, Colin A., Dahmane, Nadia, Baubet, Valérie, Wang, Zhiqiang, Bai, Feng, Pei, Xin-Hai, Rodriguez-Blanco, Jezabel, Hang, Brian, Orton, Darren, Han, Lu, Wang, Baolin, Capobianco, Anthony J., Lee, Ethan, Robbins, David J.
Publicado no Cancer Res (2014)

Hedgehog Signaling Regulates Bladder Cancer Growth And Tumorigenicity

Por Fei, Dennis Liang, Sanchez-Mejias, Avencia, Wang, Zhiqiang, Flaveny, Colin, Long, Jun, Singh, Samer, Rodriguez-Blanco, Jezabel, Tokhunts, Robert, Giambelli, Camilla, Briegel, Karoline J., Schulz, Wolfgang A., Gandolfi, A. Jay, Karagas, Margaret, Zimmers, Teresa A., Jorda, Merce, Bejarano, Pablo, Capobianco, Anthony J., Robbins, David J.
Publicado em 2012