Tipping the MYC–MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes

Por Schaub, Franz X, Cleveland, John L
Publicado no EMBO Mol Med (2014)

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

Por Ghalei, Homa, Schaub, Franz X., Doherty, Joanne R., Noguchi, Yoshihiko, Roush, William R., Cleveland, John L., Stroupe, M. Elizabeth, Karbstein, Katrin
Publicado no J Cell Biol (2015)

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function

Por Berglund, Anders E., Scott, Kristen E.N., Li, Weimin, Yang, Chunying, Fernandez, Mario R., Schaub, Franz X., Cleveland, John L., Rounbehler, Robert J.
Publicado no Oncotarget (2016)

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Por Schaub, Franz X, Reza, Md Shamim, Flaveny, Colin A, Li, Weimin, Musicant, Adele M, Hoxha, Sany, Guo, Min, Cleveland, John L, Amelio, Antonio L
Publicado no Cancer Res (2015)

Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state

Por Rounbehler, Robert J., Fallahi, Mohammad, Yang, Chunying, Steeves, Meredith A., Li, Weimin, Doherty, Joanne R., Schaub, Franz X., Sanduja, Sandhya, Dixon, Dan A., Blackshear, Perry J., Cleveland, John L.
Publicado em 2012

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Por Hoellein, Alexander, Fallahi, Mohammad, Schoeffmann, Stephanie, Steidle, Sabine, Schaub, Franz X., Rudelius, Martina, Laitinen, Iina, Nilsson, Lisa, Goga, Andrei, Peschel, Christian, Nilsson, Jonas A., Cleveland, John L., Keller, Ulrich
Publicado em 2014

CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB–MYC involvement

Por Amelio, Antonio L., Fallahi, Mohammad, Schaub, Franz X., Zhang, Min, Lawani, Mariam B., Alperstein, Adam S., Southern, Mark R., Young, Brandon M., Wu, Lizi, Zajac-Kaye, Maria, Kaye, Frederic J., Cleveland, John L., Conkright, Michael D.
Publicado em 2014

Pan-Cancer Alterations of the MYC oncogene and its Proximal Network across The Cancer Genome Atlas

Por Schaub, Franz X., Dhankani, Varsha, Berger, Ashton C., Trivedi, Mihir, Richardson, Anne B., Shaw, Reid, Zhao, Wei, Zhang, Xiaoyang, Ventura, Andrea, Liu, Yuexin, Ayer, Donald E., Hurlin, Peter J., Cherniack, Andrew D., Eisenman, Robert N., Bernard, Brady, Grandori, Carla
Publicado no Cell Syst (2018)

BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer

Por Lui, Goldie Y.L., Shaw, Reid, Schaub, Franz X., Stork, Isabella N., Gurley, Kay E., Bridgwater, Caroline, Diaz, Robert L., Rosati, Rachele, Swan, Hallie A., Ince, Tan A., Harding, Thomas C., Gadi, Vijayakrishna K., Goff, Barbara A., Kemp, Christopher J., Swisher, Elizabeth M., Grandori, Carla
Publicado no EBioMedicine (2020)

Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer

Por Xu, Chang, Nikolova, Olga, Basom, Ryan S., Mitchell, Ryan M., Shaw, Reid, Moser, Russell D., Park, Heuijoon, Gurley, Kay E., Kao, Michael C., Green, Carlos L., Schaub, Franz X., Diaz, Robert L., Swan, Hallie A., Jang, In S., Guinney, Justin, Gadi, Vijayakrishna K., Margolin, Adam A., Grandori, Carla, Kemp, Christopher J., Méndez, Eduardo
Publicado no Clin Cancer Res (2018)