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Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

The human aryl hydrocarbon receptor (hAHR) and mouse aryl hydrocarbon receptor (mAHR(b)) share limited (58%) transactivation domain (TAD) sequence identity. Compared to the mAHR(b) allele, the hAHR displays 10-fold lower relative affinity for prototypical ligands, such as 2,3,7,8 tetrachlorodibenzo-...

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Autori principali: Flaveny, Colin A., Murray, Iain A., Perdew, Gary H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840214/
https://ncbi.nlm.nih.gov/pubmed/20044593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp308
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