Pyrvinium attenuates Hedgehog signaling downstream of Smoothened

The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Li, Bin, Fei, Dennis Liang, Flaveny, Colin A., Dahmane, Nadia, Baubet, Valérie, Wang, Zhiqiang, Bai, Feng, Pei, Xin-Hai, Rodriguez-Blanco, Jezabel, Hang, Brian, Orton, Darren, Han, Lu, Wang, Baolin, Capobianco, Anthony J., Lee, Ethan, Robbins, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321822/
https://ncbi.nlm.nih.gov/pubmed/24994715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0317
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